Jean Lhermitte 1877-1959

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Lhermitte - duclos Disease :

Lhermitte-Duclos disease (LDD) is a benign neoplasm of posterior fossa, involving cerebellum. It is also known as dysplastic cerebellar gangliocytoma. It is not a true neoplasm but a hamartoma. It can be either isolated finding or associated with Cowden (multiple hamartoma syndrome). adults.

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Lhermitte-Duclos disease.

Lhermitte-Duclos disease was first described in 1920 in the literature under the names of Purkinjeoma, granular cell hypertrophy of the cerebellum, hamartoma of the cerebellum, dysplastic gangliocytoma, ganglioneuroma, and gangliomatosis of the cerebellum. Patients tend to be young adults and may present with signs of cerebellar dysfunction or increased intracranial pressure secondary to obstru...

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Lhermitte-Duclos disease.

Lhermitte-Duclos disease (dysplastic gangliocytoma of the cerebellum) is a rare benign cerebellar mass of unknown etiology which is characterized by enlargement of the cerebellar folia. Despite the controversy regarding its pathogenesis, imaging and histopathological findings are rather typical. A 17-year-old female presented with a 2-year history of progressive headaches and gait imbalance. Cr...

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In the majority o f chronic lymphocytic leukemias (CLL), proliferative B lymphocytes are thought to be frozen in vivo at a given maturat ion stage (1). Recently, several studies have emphasized that CLL cells could be driven to different iate into plasma cells in vitro (with or without proliferation) upon t r iggering by mitogens (2, 3, 4) or T cel l -der ived factors (5, 6). Th u s far, howeve...

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Lhermitte-Duclos disease and pregnancy

Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) is a rare disorder, characterized by a slowly progressive unilateral neoplastic mass of the cerebellar cortex. The histopathological findings of LhermitteDuclos disease (LDD) include the widening of the molecular layer, which is occupied by abnormal ganglion cells, absence of the Purkinje cell layer and hypertrophy of the granulan c...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 1994

ISSN: 0022-3050

DOI: 10.1136/jnnp.57.7.846